Turnover rate of brain 5-hydroxytryptamine increased by D-amphetamine
نویسندگان
چکیده
منابع مشابه
Human obesity is associated with a chronic elevation in brain 5-hydroxytryptamine turnover.
The afferent signals that evoke changes in energy intake with regard to body weight regulation are presumed to arise partly from body stores, with the most likely candidate being adipose tissue depots. However, clinical investigation of the neuronal circuitry involved in the central nervous system's processing of such satiety signals remains largely unexplored. Using percutaneously placed cathe...
متن کامل5- Hydroxytryptamine
eral kinetic systems and compares their properties (after cautioning the reader of the possible pitfalls and of the assumptions which must be made) with various biological phenomena such as regulation, regeneration, determination , gene action, pleiotropism, etc. Few biologists have been as successful as Waddington in accomplishing a synthesis between embryology and genetics. In this volume, he...
متن کاملSubcellular distribution of 5-hydroxytryptamine in the rabbit brain.
It was demonstrated by BAKER(1958,1959)that a large fraction of 5-hydroxytryptamine(5-HT)in duodenal mucosa was present in intracellular store granuels denser than the mitochondria.On the other hand,WHITTAKER(1959) reported that the brain 5-HT was chiefly found as a bound form in subcellular fractions less dense than the typical mitochondrial one,suggesting the difference between the brain and ...
متن کاملElevated environmental temperatures can induce hyperthermia during d-fenfluramine exposure and enhance 5-hydroxytryptamine (5-HT) depletion in the brain.
d-Fenfluramine (d-Fen) has been demonstrated to alter body temperature (BT), decrease 5-hydroxytryptamine (5-HT) and decrease 5-HT plasma membrane transporters (PMT) in rats. Therefore, experiments were designed to test whether a correlation existed between elevated BT and brain 5-HT depletions. It was hypothesized that d-Fen would induce hyperthermia if the environmental temperature was elevat...
متن کاملNeuropharmacology of 5-hydroxytryptamine.
This review outlines the history of our knowledge of the neuropharmacology of 5-hydroxytryptamine (5-HT; serotonin), focusing primarily on the work of U.K. scientists. The existence of a vasoconstrictive substance in the blood has been known for over 135 years. The substance was named serotonin and finally identified as 5-HT in 1949. The presence of 5-HT in the brain was reported by Gaddum in 1...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1970
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1970.tb10629.x